Characterizing the Immune Reactivity of Individuals Circulating Antibody Repertoire
Molecular Indexing of Proteins by Self Assembly (MIPSA)
Profile libraries of conformational &
Novel self-assembling system produces both peptides and full-length proteins covalently linked to unique DNA barcodes
Readout by high throughput sequencing of amplified DNA barcodes
~800 trillion antibodies in every drop of blood
Antibody profiling refers to the comprehensive analysis of an individual's antibody responses against a large set of specific antigens (antibody generators)
Antibodies, also known as immunoglobulins (Ig's), are proteins produced by the immune system in response to the presence of foreign substances, such as pathogens or allergens, or in the case of autoimmune disease, an individual's own proteins. An individual's repertoire of circulating antibodies provides a global picture of their previous and ongoing immune responses
Antibody Profiling Applications
Antibody profiling can reveal environmental exposures or infections associated with complex diseases. It can also reveal specific autoimmune antibodies that directly or indirectly contribute to mechanisms of disease.
Antibody biomarkers can play an important role in disease diagnosis, prognosis and patient stratification. Optimal patient stratification can greatly improve the success rates of clinical trials.
Avoid adverse events
Pre-existing antibodies can indicate underlying disease susceptibility relevant for adverse events, especially in response to immunomodulatory therapies. Anti-drug/vector antibodies may also interfere with therapeutic efficacy.
Antibody tests play a prominent role in clinical diagnostics. Unbiased antibody profiling can reveal the most optimal antigens and epitopes for formulation into clinical tests.
Antibody Profiling Disease Areas
Antibody profiling is used extensively in a variety of fields, including infectious disease research, vaccine development, allergy studies, autoimmune disease research, cancer immunology, and more. It helps researchers and clinicians understand the immune status of individuals or groups, identify immune-related patterns, and one day will be used to personalize treatments or interventions accordingly.
Infinity Bio's services provide insight into the immune responses of an individual or a population against specific pathogen proteins or vaccine components. In an unbiased way, we can support epidemiologic investigations of pathogen circulation or emergence, discovery of complex disease mechanisms, development of improved diagnostics, and tracking of immune responses over time at the individual or population levels.
Autoimmune Disease Research
Infinity Bio's diverse and complementary autoantibody detection products will uncover molecular targets and patterns of reactivity associated with autoimmune diseases, such as lupus, multiple sclerosis, scleroderma, etc. Let us help you understand the specific immune targets within the body's own tissues, which underly the mechanisms of these diseases.
Antibody profiling will play a prominent role in the next generation of vaccine development by helping to identify key epitopes and revealing crucial mechanistic correlates of vaccine efficacy.
Take an unbiased approach to characterizing allergic antibodies, including food allergies and environmental allergies (e.g., pollen, dust mites). We empower researchers to understand and characterize the specific allergens - at epitope resolution - involved in immune reactions, identifying biomarkers to improve diagnostic and therapeutic strategies.
Antibody profiling can be utilized in the field of cancer immunotherapy to assess the immune response against cancer cells. Take an unbiased approach to identifying tumor-specific antibodies and evaluating the efficacy of immunotherapeutic interventions, such as immune checkpoint inhibitors or monoclonal antibodies. Undesirable immune related adverse events (irAEs) can also be detected and characterized by antibody profiling.
Target and Biomarker Discovery
Let Infinity Bio help you discover novel therapeutic targets or biomarkers associated with various diseases. By analyzing the antibody profiles of patients with specific conditions, you will discover reactivity patterns or specific antibodies associated with disease presence, initiation or progression. Better patient stratification will lead to more targeted and effective treatment approaches.
Deeply characterizing each individual's unique antibody repertoire will be a critical component of true precision medicine. Gene therapies, microbiome therapies, immunomodulatory therapies - all stand to benefit from a better understanding of each patient's unique exposure history and immune profile.
Infinity Bio Profiling Services
Accelerate your Discoveries! Infinity Bio offers fast, reliable, comprehensive antibody profiling with:
bioinformatics and data analysis support to maximize your insight.